I think the original sentence is the least awkward phrasing, but maybe this would be an acceptable use of "as":
More than thirty years ago, Dr. Barbara McClintock, the Nobel Prize winner, reported that genes can
"jump," as pearls would move mysteriously from one necklace to another.
It's tricky, because the pearls are metaphorical. You would definitely need a hypothetical verb such as "would" in that clause.
Though the "as would" construction here is grammatically correct, it
logically implies that the
movement of the pearls is a reality. However, the meaning of the sentence indicates that this movement is "
just an image". Thus the
simile should be a phrase introduced by the preposition "like" and
not by a clause introduced by the conjunction "as". As mentioned, the "as would" construction would imply that the movement is a reality, something which
isn't correct.
Further, there are fundamentally
4 differences between "as" and "like".
1.
As introduces clauses (which have verbs) and
like introduces phrases (which don't have verbs).
2.
As clause construction is used to introduce comparisons that
are real.
Like phrase constructions are preferred when making comparisons that are
not real but imaginary. (See the above McClintock example)
3. "As" is also used as a
substitute for "in the capacity of". Eg.
As the president of USA, George Bush.....
4. Idiomatic differences:
Used as (Correct)
Used Like (Incorrect) /
Regarded as (Correct),
Regarded Like (Incorrect). There is just
one exception (that I have come across) to the idiomatic constructions using the verb "act", where one has to
infer the meaning before using "as/like". "Act as" is used when a
function of an inanimate object is described. Eg.
In the flood, the wall acted as a dam. However, "act" is followed by
like to mean
to behave or comport oneself and describes the action of a person. Eg.
He acted like a fool.
I hope this post helps. :-)
Pooja